Twórca instytucjonalny:

Department of Experimental and Clinical Neuropathology MMRI

Współtwórca:

K.Wiśniewska, dr

Opis:

Clinical, anatomical and histological diagnosis

Abstrakt:

Histological diagnosis: Meningoencephalitis metastatica. Autopsy examination of 14-year-old patient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained by Hematoxylin-eosin, cresyl violet, mucikarmine, PAS, alcian blue and Heidenhain’s azan.In the meninges of the entire CNS, inflammatory granulation tissue composed mostly of histiocytic and plasmocytic cells with few epithelioid cells, lymphocytes, leukocytes, macrophages and Russell bodies. Focally fresh blood was seen. Among both plasma and histiocytic cells multinucleated forms and single mitosis images were observed. A similar type of inflammatory infiltration was present in the neural parenchyma of the cerebral hemispheres in the brainstem, cerebellum, medulla, and in both gray and white structures in the form of granulomas. A significant reaction from the micro and macroglia which is sometimes the primary element of the infiltrate, and formation of large glial lumps, were observed in these areas. Gramm /-/ granules corresponding to bacteria were seen along the vessels and in the neural tissue. In the cortex also necrosis as well as neuronal atrophy and ischemic changes were seen. In Heidenhain's staining in necrotic areas and their vicinity partial or complete demyelination. In addition, throughout the nervous system, significant features edema, congestion, and glial activation and proliferation were observed.

Format:

pdf

Identyfikator zasobu:

oai:rcin.org.pl:193512

Język:

pol

Język streszczenia:

eng

Prawa:

Creative Commons Attribution BY 4.0 license

Zasady wykorzystania:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitalizacja:

Mossakowski Medical Research Institute PAS

Lokalizacja oryginału:

Library of the Mossakowski Medical Research Institute PAS

Dofinansowane ze środków:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Dostęp:

Open