File of histopathological evaluation of nervous system diseases (1966) - nr 29/66

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Title: File of histopathological evaluation of nervous system diseases (1966) - nr 29/66

Abstract:

Histological diagnosis: Edema uremic encephalopathy. Autopsy examination of 57-year-old patient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with H-E, Cresyl violet, Heidenhain and Van Gieson's method.At all intersections in the white matter of the brain, cerebellum, and medulla, small poorly defined foci of myelin translucencies were found. At high magnification, swelling and disintegration of myelin fibers and swelling of glial cell protoplasm were visible in these fields. Sometimes the foci were concentrated around small vessels, sometimes they were located completely independent from the vessels. Around larger vessels areas of typical spongiform necrosis and extensive areas of incomplete and not sharply demarcated demyelination were observed. The gray matter was not affected originally. Numerous translucencies and neuronal degeneration corresponded to altered cortical capillaries. The whole picture most closely resembled edematous uremic encephalopathy. A clinical syndrome of psychiatric disorders could also support this diagnosis. In urine obtained post-mortem from the kidney, pathological changes were found.Histological diagnosis: Encephalopathia oedematosa vere similiter uraemicae.