Institutional creator:

Department of Experimental and Clinical Neuropathology MMRI

Contributor:

M. Marciniak, lek. ; K. Wiśniewska, dr

Description:

Clinical, anatomical and histological diagnosis

Abstract:

Histological diagnosis: Encephalomalacia inveterata et rubra recens. Haemorrhagia subarach- noidealis. Hyperaemia et oedema cerebri. Arteriosclerosis universalis.Encephalomalacia. Subarachnoid haemorrhage. Cerebral congestion and oedema. Atherosclerosis.Autopsy examination of 69-year-old patient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained by H-E and Van Gieson's stain.In the left temporal lobe an old focus of malacia destroying the white matter and lower layers of the cortex was observed. It was in the phase of glial-mesodermal organization. In the centre of the focus, significant loss of neural tissue with a tendency to cavity formation was observed. At the margins, connective tissue network, macrophages with hemosiderin, gemistiocytic glial and loosened tissue structure were noticed. In the left basal ganglia, a foci of haemorrhagic necrosis destroying part of the island, the last capsule, the external capsule and the inner surface of the shell was visible. Tissue was is in the dissection phase, hence there were numerous macrophages at its edges. Activation and proliferation of mesodermal-glial tissue was significant. Large vacuolations in the cortex in all analyzed areas and ischemically diseased, fatty degenerated cells were observed. In the whole nervous system features of edema; congestion, atherosclerotic changes were seen. In the meninges in the subarachnoid space blood, macrophages and lymphocytes were present.Histological diagnosis: Encephalomalacia inveterata et rubra recens. Haemorrhagia subarach- noidealis. Hyperaemia et oedema cerebri. Arteriosclerosis universalis.Encephalomalacia. Subarachnoid haemorrhage. Cerebral congestion and oedema. Atherosclerosis.

Format:

pdf

Resource Identifier:

oai:rcin.org.pl:193420

Language:

pol

Language of abstract:

eng

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open