Institutional creator:

Department of Experimental and Clinical Neuropathology MMRI

Contributor:

K.Wiśniewska, dr

Description:

Clinical, anatomical and histological diagnosis

Abstract:

Histological diagnosis: Inflitrationes leucaemicae leptomeningum et cerebri. Autopsy examination of 19-month-old patient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with H-E, Cresyl violet and Heidenhein method.Abundant diffuse and perivascular leukemic infiltrates were observed throughout the meningeal system. Cells with features of significant damage were predominant. In some places abnormal forms of division were seen. In the nervous tissue infiltrations were observed in the visual band, lateral to Reichert's nucleus and scattered smaller infiltrations in both white and grey matter of cerebral hemispheres, cerebellum and brain stem. The infiltrates never crossed the perivascular space. A pronounced glial reaction was absent. In the cortex, small nerve cell defects, ischemic, chronic type conditions were evident, most prominent in the cingulate gyrus. A single layer of nerve cells was present in the corpus callosum in the upper part. In parts, the lining of the lateral ventricles was damaged and infiltrated. Features of edema and congestion were evident throughout the nervous system

Format:

pdf

Resource Identifier:

oai:rcin.org.pl:193361

Language:

pol

Language of abstract:

eng

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open