Institutional creator:

Department of Experimental and Clinical Neuropathology MMRI

Contributor:

H. Lewicka-Wysocka, dr ; E.Osetowska, prof.

Description:

Clinical, anatomical and histological diagnosis

Abstract:

Histological diagnosis: Encephalolalaciae multiplices recentes et inveterate in regione nucleorum basalium hemisphaeri utriusque. Status lacuneris Oedema et hyperaemia cerebri. Arteriosclerosis cerebri. Autopsy examination of 76-year-old patient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with Hematoxylin-eosin, PAS and van Gieson method.In the right basal ganglia a small focus of malacia in the mesodermal-glial organization phase was found. Numerous macrophages and a network of young vessels were visible in the center of the focus. In the left basal ganglia, a triangular focus, involving the insula cortex and the extrema capsule, was seen. The focus was in the stage of advanced glial-mesodermal organization. Numerous gemistiocytes, stimulated glial cells and single macrophages were observed in the necrotic area. Besides, multiple perivascular necroses were found bilaterally in the striatum. There was extensive neuronal atrophy in the cortex. Preserved neurocytes showed features of ischemic damage and steatosis. Numerous amyloid globules were present in the fine layer. Thalamic cells contained high amounts of lipofuscin. Atrophy and steatosis were especially present in the olive cells. Throughout the CNS, vessels were congested and endothelium was stimulated. The vessel walls showed medium-grade vitreous and fibrous changes.i

Format:

pdf

Resource Identifier:

oai:rcin.org.pl:193414

Language:

pol

Language of abstract:

eng

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open