Institutional creator:

Department of Experimental and Clinical Neuropathology MMRI

Contributor:

H. Lewicka-Wysocka, lek. ; K. Wiśniewska, dr

Description:

Clinical, anatomical and histological diagnosis

Abstract:

Histological diagnosis: Encephalomacia recens et inveterata. Arteriosclerosis. Autopsy examination of 71-year-old patient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with Hematoxylin-eosin, van Gieson, PAS and Alcian blue.In the left hemisphere, a fresh focus of malacia involving the inferior frontal gyrus, basal ganglia, insula, superior temporal gyrus, lateral temporal-occipital gyrus, and hippocampus was evident. The focus was in the phase of leukocyte infiltration and early macrophage demolition. In the necrotic area, the anatomical pattern was blurred, with decreased pigmentation and reduced number of cellular elements. Foci of incomplete necrosis were found in the ammonal cortex h1 - h3. Ischemic, chronic and steatotic conditions were observed in nerve cells of all areas. Features of edema and congestion were present throughout the CNS: vessels were filled with blood, endothelium was swollen, Virchov-Robin spaces were dilated. The tissue structure was spongy. Fibrous and occasionally vitreous changes were found in the vessel walls. The meninges also showed features of congestion, macrophages and histiocyte-like cells were seen around the vessels. In the PAS reaction positive substances were present in macrophages, reactive glial and amyloid bodies

Format:

pdf

Resource Identifier:

oai:rcin.org.pl:193396

Language:

pol

Language of abstract:

eng

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open