Institutional creator:

Department of Experimental and Clinical Neuropathology MMRI

Contributor:

M.Dąmbska, dr hab.

Place of publishing:

Warsaw

Description:

Clinical, anatomical and histological diagnosis

Abstract:

Histological diagnosis: Foci encephalomalaciae rubrae hemispherii utriusque et cerebelli cortico-subcorticales. Arteriosclerosis et atheromatosis vasorum meningealium precipue in regione fissae Sylvii. Autopsy examination of 68-year-old patient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with Hematoxylin-eosin and Van Gieson's method.In the inferior frontal gyrus, insula, hippocampus, occiput and cerebellum, extensive foci of hemorrhagic malacia were found.The localization of all lesions was cortical-subcortical, in some areas cortical malacia with numerous small hemorrhages in its area predominated, in others particularly subcortical white matter was disintegrated.In fields of malacia, leukocytic infiltration and symptomatic perivascular reaction was observed. In several subcortical fields foci of tissue thinning were seen, which gave the impression of incomplete necrosis, older than fields of fresh malacia. In several subcortical fields foci of tissue thinning were seen, which gave the impression of incomplete necrosis, older than fields of fresh thinning.The severity of arteriosclerotic changes in the meningeal vessels, especially around the insula, was enormous. The vessel walls were very markedly thickened and the lumen irregularly narrowed. A mainly macrophage-like symptomatic reaction was observed in the meninges.iatosis vasorum meningealium precipue in regione fissae Sylvii . Autopsy examination of 68-year-old patient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with Hematoxylin-eosin and Van Gieson's method.In the inferior frontal gyrus, insula, hippocampus, occiput and cerebellum, extensive foci of hemorrhagic malacia were found.The localization of all lesions was cortical-subcortical, in some areas cortical malacia with numerous small hemorrhages in its area predominated, in others particularly subcortical white matter was disintegrated.In fields of malacia, leukocytic infiltration and symptomatic perivascular reaction was observed. In several subcortical fields foci of tissue thinning were seen, which gave the impression of incomplete necrosis, older than fields of fresh malacia. In several subcortical fields foci of tissue thinning were seen, which gave the impression of incomplete necrosis, older than fields of fresh thinning.The severity of arteriosclerotic changes in the meningeal vessels, especially around the insula, was enormous. The vessel walls were very markedly thickened and the lumen irregularly narrowed. A mainly macrophage-like symptomatic reaction was observed in the meninges.

Format:

pdf

Resource Identifier:

oai:rcin.org.pl:197155

Language:

pol

Language of abstract:

eng

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open