File of histopathological evaluation of nervous system diseases (1965) - nr 6/65

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Title: File of histopathological evaluation of nervous system diseases (1965) - nr 6/65

Abstract:

Histological diagnosis: Infarctus multilocularis certicis cerebri cerebelli et trunci cerebri. Atrophia lamellaris cerebelli. Arteriosclerosis gradu magno.Autopsy examination of 70-year-old patient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with Nissl, Bielschowsky and Van Gieson's method.In the frontal, temporal, parietal, and most severely in the occipital cortex, multiple foci of malacia were seen, most often in the glial-mesodormal organization phase. Outside the foci, atrophy of neurocytes, leading to obliteration of the layered structure of the cortex, was observed. The remaining cells were mostly altered - they showed features of chronic ischemic disorder, some were steatotic. Foci of early malacia were found in the pons, similarly in the region of the nucleus accumbens and unilaterally in the inferior olive. Slight atrophy of Purkinje cells was seen in the cerebellum, and homogenization changes were seen in the preserved cells. The vasculature was generally fibrotic, often hypertrophic. The most significant changes were observed in the basal ganglia, then in the white matter. In the cortex changes were insignificant. In the basal ganglia the vessels were atheromatically altered. Frequently, infiltrates of lymphocyte-like cells and single macrophages were present near the vessels. Besides, features of edema and congestion were found.