File of histopathological evaluation of nervous system diseases (1965) - nr 51/65

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Title: File of histopathological evaluation of nervous system diseases (1965) - nr 51/65

Abstract:

Histological diagnosis: Focus haemorrhagicus ad encephalomalaciam in regione nucleorum basalium dextrorum. Haemorrhagia subarachnoidea lis. Status lacunaris. Encephalomalacia cerebelli. Arterio et arteriolosclerosis gr. magno. Oedema et hyperaemia cerebri.Autopsy examination of 73-year-old patient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with H-E, Heidenhain and Van Gieson's method.The margin of the hemorrhagic focus was seen in the outer part of the right basal nucleus. The tissue surrounding the focus was severely thinned, without macrophage reaction. In addition, tissue disintegration along the ventricular wall was observed in the basal nuclei, and astroglial reaction was present. Perivascular sinusoids were found, large and numerous. A second large focus of malacia, also without macrophage infiltration, was present in the cerebellar cortex. Small foci of disintegration without cellular reaction were found in the griseum pontis and white matter of the cerebral hemisphere. These foci were filled with macrophages. Extravasated blood was seen in the subarachnoid space. There was prominent cellular and fibrous reaction from the soft meninges. Areas of spongiform changes were seen throughout the cerebral cortex, most expressed in the central region. Features of edema and congestion and gliosis were observed throughout the brain. Many nerve cells contained abundant lipofuscin deposits. Almost all vessels showed atherosclerotic lesions causing severe narrowing of the lumen.