Twórca instytucjonalny:

Department of Experimental and Clinical Neuropathology MMRI

Współtwórca:

Osetowska, Ewa Prof. dr med

Miejsce wydania:

Warsaw

Opis:

Clinical, anatomical and histological diagnosis

Abstrakt:

Histological diagnosis: Glioblastome multiforme.Autopsy examination of 68-year-old patient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with Hematoxylin-eosin and van Gieson method.An extremely pleomorphic tumor originating from glial tissue was found. In the central parts it contained numerous necrotic and hemorrhagic foci. In the parts distal to the necrotic lesions, three types of tissue were present: perivascular aggregates, sometimes with astroblastoma-like arrangements; loose structureless aggregates of small, poorly differentiated cells, and occasionally single mast cell astrocytes were seen perivascularly - this part of the tumor resembled the structure of glioma immaturum. The peripheral parts showed accumulations of variously shaped cells, often large hyperchromatic cells, although without clear nuclear conglomerates, and numerous cells with abnormal mitoses, spindle cells and astrocyte-like cells. The tumor transitioned indistinctly into an environment in which tumor cells were shuffled with stimulated glial and with retained neurons.

Format:

pdf

Identyfikator zasobu:

oai:rcin.org.pl:210130

Język:

pol

Język streszczenia:

eng

Prawa:

Creative Commons Attribution BY 4.0 license

Zasady wykorzystania:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitalizacja:

Mossakowski Medical Research Institute PAS

Lokalizacja oryginału:

Library of the Mossakowski Medical Research Institute PAS

Dofinansowane ze środków:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Dostęp:

Open