File of histopathological evaluation of nervous system diseases (1963) - nr 22/63

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Title: File of histopathological evaluation of nervous system diseases (1963) - nr 22/63

Abstract:

Histological diagnosis: Focii encephalomalaciae multiplices partim cum haemorrhagies secundaris.Autopsy examination of 63-year-old patient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with Hematoxylin-eosin and van Gieson.Vascular foci of various age were found in all areas examined. In specimens from the left hemisphere in the temporal region, a focus of malacia during macrophage dissection phase involving the hippocampus was present. Numerous capillaries were penetrating into the focus. In some areas, the tissue was completely disintegrated, with large clusters of macrophages. At the periphery, the tissue was narcotically altered and stimulated glial cells as well as remnants of nerve cells were visible. Within the circumscribed focus, hemorrhagic lesions were evident, most severe in its central part. An inflammatory reaction with marked macrophage involvement was observed in the adjacent meninges. The oldest foci of malacia were seen in the insula and its nearest surroundings including the junction of temporal and parietal lobes. In the anterior part of the temporal lobe, necrotic lesions were fresh, with quite numerous scattered leukocytes visible in the tissue and around the vessels. In the basal ganglia there were small vessels filled with leukocytes, in larger ones leukocytes were adhering to vessels walls. In their vicinity there were fields of necrotic tissue with leukocytes, the spaces around the vessels were dilated. In places, foci of further disintegration with few macrophages, surrounded by stimulated glia with hypertrophic forms of astroglia were observed. Pseudocalcium deposits were accumulated in the walls of the globus pallidus vessels.