Nucleic acid in sifu hybridization; from ISH to DIRVISH
Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS
In situ hybridization (ISH) provides a highly sensitive method for the detection of specificnucleic acid sequences in cells, nuclei and metaphase chromosomes. This technique has beenimproved continuously since it was first established in 1969. Especially fluorescent in situ hybridization (FISH) rapidly replaced radioactive procedures and became a conventional tool incytogenetic research. ISH plays an increasingly important role in a variety of research areas ofmedicine, genetics and plant breeding. It has been successfully applied for chromosome orchromosome fragments identification, chromosomal abnormalities detection, gene mapping orspecific DNA sequences localization.
Biotechnologia, vol.29, 2 (1995)-.
0860-7796 ; oai:rcin.org.pl:147872 ; IChB B-25
Library of Institute of Bioorganic Chemistry PAS
Creative Commons Attribution BY-SA 4.0 license
Institute of Bioorganic Chemistry of the Polish Academy of Science
Institute of Bioorganic Chemistry of the Polish Academy of Science
Nov 20, 2020
Nov 20, 2020
1282
https://rcin.org.pl./publication/183456
Edition name | Date |
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Hybrydyzacja kwasów nukleinowych in situ: od ISH do DIRVISH | Nov 20, 2020 |
Borkowska, Bożenna
Ziółkowski, Piotr Babula- Skowrońska, Danuta Kaczmarek, Małgorzata Cieśla, Agata Sadowski, Jan