Szramka, Bożena ; Kurlenda, Julianna ; Podhajska, Anna J.
Thiol-activated hemolysins as virulence markers of bacteria
Komitet Biotechnologii PAN ; Instytut Chemii Bioorganicznej PAN
The article contains information regarding the similarities and differencesbetween proteins of the thiol-activated cytolysins family (TACY). Members ofthis group of haemolysins are produced by several species of Gram-positive bacteria {Listeria spp., Streptococcus spp., Bacillus spp., Clostridium spp.,) and also byGram-negative Klebsiella spp. Their cytolytic activity is sensitive to oxygen andcan be restored by adding reducing compounds. TACY bind to cholesterol-containing membranes to form pores. Preincubation of the toxin with smallamounts of cholesterol inhibits hemolytic activity as well as cytolysis ofeucaryotic cells. Members ofthe group show 40-70% similarity in amino acid sequence, and contain an almost invariant Trp-rich undecapeptide sequence(ECTGLAWEWWR). The TACY are important virulence factors. Recently increased use has been made of molecular methods (PCR, hybridization) in the detection and identification of the TACY producing bacteria.
Biotechnologia, vol.54, 3 (2001)-.
0860-7796 ; oai:rcin.org.pl:138884 ; IChB B-50
Biblioteka Instytutu Chemii Bioorganicznej PAN
Licencja Creative Commons Uznanie autorstwa-Na tych samych warunkach 4.0
Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
Oct 2, 2020
Sep 14, 2020
317
https://rcin.org.pl./publication/174177
Edition name | Date |
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Hemolizyny aktywowane tiolem jako markery wirulencji bakterii | Oct 2, 2020 |
Borkowska, Bożenna
Ziółkowski, Piotr Babula- Skowrońska, Danuta Kaczmarek, Małgorzata Cieśla, Agata Sadowski, Jan
Królicka, Aleksandra Kurlenda, Julianna Łojkowska, Ewa
Nowak, Jacek K.
Waleron, Krzysztof Nakonieczna, Joanna Waleron, Małgorzata Podhajska, Anna J.