Szramka, Bożena ; Kurlenda, Julianna ; Podhajska, Anna J.
Thiol-activated hemolysins as virulence markers of bacteria
Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS
The article contains information regarding the similarities and differencesbetween proteins of the thiol-activated cytolysins family (TACY). Members ofthis group of haemolysins are produced by several species of Gram-positive bacteria {Listeria spp., Streptococcus spp., Bacillus spp., Clostridium spp.,) and also byGram-negative Klebsiella spp. Their cytolytic activity is sensitive to oxygen andcan be restored by adding reducing compounds. TACY bind to cholesterol-containing membranes to form pores. Preincubation of the toxin with smallamounts of cholesterol inhibits hemolytic activity as well as cytolysis ofeucaryotic cells. Members ofthe group show 40-70% similarity in amino acid sequence, and contain an almost invariant Trp-rich undecapeptide sequence(ECTGLAWEWWR). The TACY are important virulence factors. Recently increased use has been made of molecular methods (PCR, hybridization) in the detection and identification of the TACY producing bacteria.
Biotechnologia, vol.54, 3 (2001)-.
0860-7796 ; oai:rcin.org.pl:138884 ; IChB B-50
Library of Institute of Bioorganic Chemistry PAS
Creative Commons Attribution BY-SA 4.0 license
Institute of Bioorganic Chemistry of the Polish Academy of Science
Institute of Bioorganic Chemistry of the Polish Academy of Science
Oct 2, 2020
Sep 14, 2020
316
https://rcin.org.pl./publication/174177
Edition name | Date |
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Hemolizyny aktywowane tiolem jako markery wirulencji bakterii | Oct 2, 2020 |
Borkowska, Bożenna
Ziółkowski, Piotr Babula- Skowrońska, Danuta Kaczmarek, Małgorzata Cieśla, Agata Sadowski, Jan
Królicka, Aleksandra Kurlenda, Julianna Łojkowska, Ewa
Waleron, Krzysztof Nakonieczna, Joanna Waleron, Małgorzata Podhajska, Anna J.