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Gene therapy of cardiovascular diseases
Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS
Despite progress in pharmacotherapy, there is still a lack of efficient treatment of advanced stages of cardiovascular diseases. Therefore, great expectations are connected with gene therapy. First clinical experiments of gene transfer of vascular endothelial growth factor (VEGF) were carried out in 1994-1998 on patients with critical leg ischemia. They resulted in the improvement of vascularisation and prevented the amputation of the limbs. Promising results have been also obtained with DNA decoys binding the EF2 transcription factor. In this way, the expression of genes enhancing the proliferation of vascular smooth muscle cells have been inhibited and in consequence the narrowing of the lumen of arterio-venous bypasses have been inhibited.
Biotechnologia, vol.66, 3 (2004)-.
application/pdf ; application/pdf
0860-7796 ; oai:rcin.org.pl:113846
Library of Institute of Bioorganic Chemistry PAS
Creative Commons Attribution BY-SA 4.0 license
Institute of Bioorganic Chemistry of the Polish Academy of Science
Institute of Bioorganic Chemistry of the Polish Academy of Science
Oct 2, 2020
Feb 18, 2020
224
https://rcin.org.pl./publication/142172
Edition name | Date |
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Terapia genowa chorób układu krążenia | Oct 2, 2020 |
Józkowicz, Alicja Dulak, Józef
Stopa, Magdalena Dulak, Józef Józkowicz, Alicja
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