Subtitle:

Characterization of mammalian oocyte competence to undergo fertilization and embryonic development: I. Nuclear maturation and molecular aspects of its regulation

Publisher:

Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS

Abstract:

Near the end of the growth phase, mammalian oocyte achieves competence to undergo three aspects of maturation, i.e. nuclear, cytoplasmic and genomic. All these processes are essential for the formation of an egg having the capacity for fertilization and development. This review will consider the aspects of molecular events during the process of nuclear maturation. Meiotic maturation of an oocyte is under the control of the cell cycle molecules, of which cAMP, MPF and MAP kinases seem to be the most important. The present findings regarding Ringo protein and cdc25b kinase as modulators of MPF activity and mechanism of MPF activation are discussed. Moreover, the roles of the FF-MAS, ribo- somal S6 kinase p90''s'<, POLO like kinases and the newly discovered proteins MISS and formin-2 are described.

Relation:

Biotechnologia, vol.66, 3 (2004)-.

Volume:

66

Issue:

3

Start page:

140

End page:

151

Detailed Resource Type:

Article

Format:

application/pdf ; application/pdf

Resource Identifier:

0860-7796 ; oai:rcin.org.pl:119259

Source:

Library of Institute of Bioorganic Chemistry PAS

Language:

pol

Language of abstract:

eng

Temporal coverage:

1988-2010

Rights:

Creative Commons Attribution BY-SA 4.0 license

Terms of use:

Copyright-protected material. [CC BY-SA 4.0] May be used within the scope specified in Creative Commons Attribution BY-SA 4.0 license, full text available at:

Digitizing institution:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Original in:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open