Structure, expression and engineering of miik protein genes
Komitet Biotechnologii PAN ; Instytut Chemii Bioorganicznej PAN
Expression of milk protein genes is regulated by hormones, growth factors and extracellularmatrix. Prolactin, the major lactogenic hormone, promotes all stages of casein gene expression.Besides prolactin, also growth hormone may directly induce expression of milk protein genes.Computer analysis, mutation experiments and DNA-protein binding experiments enabled identification of mammary-specific transcription factors and cis-regulatoiy sequences in milk proteingene promoters. Also, transgene technology enables recognition of regulatory sequences in milkprotein genes. Moreover, transgenic animals carrying structural genes of human proteins fusedto mammary specific promoters are considered as living “bioreactors” designated to producehuman proteins for pharmaceutical use.
Biotechnologia, vol.33, 2 (1996)-.
0860-7796 ; oai:rcin.org.pl:147104 ; IChB B-29
Biblioteka Instytutu Chemii Bioorganicznej PAN
Licencja Creative Commons Uznanie autorstwa-Na tych samych warunkach 4.0
Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
Nov 13, 2020
Nov 13, 2020
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https://rcin.org.pl./publication/182730
Edition name | Date |
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Structure, expression and engineering of miik protein genes | Nov 13, 2020 |
Borkowska, Bożenna
Ziółkowski, Piotr Babula- Skowrońska, Danuta Kaczmarek, Małgorzata Cieśla, Agata Sadowski, Jan
Zwierzchowski, Lech Reklewski, Zygmunt
Maj, Andrzej Zwierzchowski, Lech
Nowak, Jacek K.