Twórca instytucjonalny:

Mossakowski Medical Research Center Polish Academy of Sciences. Department of Neuromuscular Diseases

Współtwórca:

Walczak, Ewa

Miejsce wydania:

Warsaw

Opis:

Electron microscopy analysis of the heart biopsy

Abstrakt:

Ultrastructural analysis revealed numerous changes in the analyzed biopsy. Within the cardiomyocytes large areas completely devoid of myofibrils were observed. Myofibrils disorganization was common (Figs. 1,2). In areas devoid of myofibrils, lipofuscin deposits were visible, as well as accumulation of altered mitochondria, characterized by a bright matrix and loss of mitochondrial cristae (Figs. 3-6). Features of laminopathy were observed. Nuclei of cardiomyocytes were deformed, with changes in the shape including numerous indentations inthe nuclear envelope. Many nuclei showed breaks in the nuclear membrane, which was associated with penetration of cell organelles into the nuclei (Figs. 7-12). Abundant fibrosis was observed in the extracellular space (Fig. 13).

Szczegółowy typ zasobu:

Files ; Photography

Format:

pdf

Identyfikator zasobu:

oai:rcin.org.pl:159944

Język:

pol ; eng

Prawa:

Creative Commons Attribution BY 4.0 license

Zasady wykorzystania:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitalizacja:

Mossakowski Medical Research Institute PAS

Lokalizacja oryginału:

Library of the Mossakowski Medical Research Institute PAS

Dofinansowane ze środków:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Dostęp:

Open