Subtitle:

Design of new thrombin inhibitors

Publisher:

Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS

Abstract:

Thrombin inhibitors are anticoagulants that inhibit clot formation. The most potent, knownthrombin inhibitor is hirudin, a 65 amino acid protein isolated from the salivary glands of themedicinal leech. An X-ray three — dimensional structure of the complex of hirudin with humana-thrombin has been recently reported. This review article describes the design based on thecrystal structure, of new synthetic hirudin analogs with reduced sequence and enhanced proteolytic stability.

Relation:

Biotechnologia, vol.25, 2 (1994)-.

Volume:

25

Issue:

2

Start page:

138

End page:

151

Detailed Resource Type:

Article

Format:

application/pdf

Resource Identifier:

0860-7796 ; oai:rcin.org.pl:148715 ; IChB B-21

Source:

Library of Institute of Bioorganic Chemistry PAS

Language:

pol

Language of abstract:

eng

Temporal coverage:

1988-2010

Rights:

Creative Commons Attribution BY-SA 4.0 license

Terms of use:

Copyright-protected material. [CC BY-SA 4.0] May be used within the scope specified in Creative Commons Attribution BY-SA 4.0 license, full text available at:

Digitizing institution:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Original in:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open