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Design of new thrombin inhibitors
Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS
Thrombin inhibitors are anticoagulants that inhibit clot formation. The most potent, knownthrombin inhibitor is hirudin, a 65 amino acid protein isolated from the salivary glands of themedicinal leech. An X-ray three — dimensional structure of the complex of hirudin with humana-thrombin has been recently reported. This review article describes the design based on thecrystal structure, of new synthetic hirudin analogs with reduced sequence and enhanced proteolytic stability.
Biotechnologia, vol.25, 2 (1994)-.
0860-7796 ; oai:rcin.org.pl:148715 ; IChB B-21
Library of Institute of Bioorganic Chemistry PAS
Creative Commons Attribution BY-SA 4.0 license
Institute of Bioorganic Chemistry of the Polish Academy of Science
Institute of Bioorganic Chemistry of the Polish Academy of Science
Nov 26, 2020
Nov 26, 2020
145
https://rcin.org.pl./publication/184123
Edition name | Date |
---|---|
Projektowanie nowych inhibitorów trombiny | Nov 26, 2020 |
Borkowska, Bożenna
Ziółkowski, Piotr Babula- Skowrońska, Danuta Kaczmarek, Małgorzata Cieśla, Agata Sadowski, Jan