Konieczny, Leszek ; Piekarska, Barbara ; Roterman, Irena ; Rybarska, Janina ; Stopa, Barbara ; Zemanek, Grzegorz
Antibodies and drug-carriers in targeted therapy - progress and limitations
Komitet Biotechnologii PAN ; Instytut Chemii Bioorganicznej PAN
The paper addresses to problems of carriers and antibodies in targetedtherapy. Also the new material ofliquid crystalline nature, designed for use as adrug vehicle in the immune targeting technique is presented and its property isdiscussed. Obtained by self-assembling, the ribbon-like supramolecular organisation products of some azo-dyes, particularly including Congo red and Evansblue, form micellar bodies of this carrier. They bind spontaneously and selectively to immune complexes but not to free antibodies. The binding strongly enhances the antigen - antibody interaction. Micelles ofthe carrier composed ofself-assembled molecules easily incorporate many foreign substances includingdrugs, favouring however those of possibly planar molecules. The excess of carrier leaves the organism rapidly through the urine tract, reducing the possibleside effects. The nature of chromonic liquid crystalline material is suitable formany modifications and adapting elaboration.
Biotechnologia, vol.54, 3 (2001)-.
0860-7796 ; oai:rcin.org.pl:138851 ; IChB B-50
Biblioteka Instytutu Chemii Bioorganicznej PAN
Licencja Creative Commons Uznanie autorstwa-Na tych samych warunkach 4.0
Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
Oct 2, 2020
Sep 14, 2020
503
https://rcin.org.pl./publication/174132
Edition name | Date |
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Przeciwciała i nośniki leków w terapii celowanej - postęp i ograniczenia | Oct 2, 2020 |
Borkowska, Bożenna
Ziółkowski, Piotr Babula- Skowrońska, Danuta Kaczmarek, Małgorzata Cieśla, Agata Sadowski, Jan
Nowak, Jacek K.