Inny tytuł:

Functionalization of a cis-diol system of ribonucleosides using anhydrocyclic structures

Wydawca:

Instytut Chemii Bioorganicznej PAN

Miejsce wydania:

Poznań

Opis:

Praca wykonana w Zakładzie Chemii Nukleozydów i Nukleotydów Instytutu Chemii Bioorganicznej PAN w Poznaniu pod kierunkiem prof. dr hab. Jerzego Boryskiego

Uzyskany tytuł:

PhD

Dyscyplina :

chemia bioorganiczna

Typ obiektu:

Thesis

Abstrakt:

Nucleosides modified in the 2’ and 3’ positions are known for many years and involve many important, bioactive compounds. This group consist of derivatives of 2’,3’-dideoxy or 2’,3’-dideoxy-didehydro types, derivatives with additional substituents or substituents instead of hydroxyl groups. These compounds are targeted against viruses and tumors. Anhydrocyclic structures have been known since the middle of the 20th century. However, their utility seems not to be fully explored and described. The number of possible to obtain through anhydrocyclic synthons 2’,3’-dimodified derivatives is very vast, taking under consideration different combinations of S-alkyl, S-aryl, O-alkyl, O-aryl, halogen, triazole, amine and azide substituents in both pyrimidine and purine nucleosides.

Strona pocz.:

1

Strona końc.:

195

Szczegółowy typ zasobu:

D. Sc. Thesis

Format:

application/pdf

Identyfikator zasobu:

d-254 ; oai:rcin.org.pl:80741

Język:

pol

Język streszczenia:

eng

Prawa:

Creative Commons Attribution BY-SA 4.0 license

Zasady wykorzystania:

Copyright-protected material. [CC BY-SA 4.0] May be used within the scope specified in Creative Commons Attribution BY-SA 4.0 license, full text available at:

Digitalizacja:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Lokalizacja oryginału:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Dofinansowane ze środków:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Dostęp:

Open