Subtitle:

Functionalization of a cis-diol system of ribonucleosides using anhydrocyclic structures

Publisher:

Instytut Chemii Bioorganicznej PAN

Place of publishing:

Poznań

Description:

Praca wykonana w Zakładzie Chemii Nukleozydów i Nukleotydów Instytutu Chemii Bioorganicznej PAN w Poznaniu pod kierunkiem prof. dr hab. Jerzego Boryskiego

Degree name:

PhD

Degree discipline :

chemia bioorganiczna

Type of object:

Thesis

Abstract:

Nucleosides modified in the 2’ and 3’ positions are known for many years and involve many important, bioactive compounds. This group consist of derivatives of 2’,3’-dideoxy or 2’,3’-dideoxy-didehydro types, derivatives with additional substituents or substituents instead of hydroxyl groups. These compounds are targeted against viruses and tumors. Anhydrocyclic structures have been known since the middle of the 20th century. However, their utility seems not to be fully explored and described. The number of possible to obtain through anhydrocyclic synthons 2’,3’-dimodified derivatives is very vast, taking under consideration different combinations of S-alkyl, S-aryl, O-alkyl, O-aryl, halogen, triazole, amine and azide substituents in both pyrimidine and purine nucleosides.

Start page:

1

End page:

195

Detailed Resource Type:

D. Sc. Thesis

Format:

application/pdf

Resource Identifier:

d-254 ; oai:rcin.org.pl:80741

Language:

pol

Language of abstract:

eng

Rights:

Creative Commons Attribution BY-SA 4.0 license

Terms of use:

Copyright-protected material. [CC BY-SA 4.0] May be used within the scope specified in Creative Commons Attribution BY-SA 4.0 license, full text available at:

Digitizing institution:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Original in:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open