Subtitle:

Chemical Combinatorial Libraries — Their Synthesis and Applications

Publisher:

Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS

Abstract:

The paper reviews the new methodologies of synthesis and screening of combinatorial libraries of chemical compounds (CCL). The original classification of chemical combinatorial librariesis presented. The combinatorial libraries of chemical compounds are the collections of low (peptides, their analogues, oligonucleotides etc.) or high molecular compounds (fragment antibodies,chemically modified phages etc.). They can be obtained via chemical or chemical/biological routesand screened with labelled acceptor (substrate) molecules in order to reveal those of interactinglibrary entities which best meet the selection criteria (conditions of selection). The potentialapplications of CCLs in basic research and technology are indicated.

Relation:

Biotechnologia, vol.32, 1 (1996)-.

Volume:

32

Issue:

1

Start page:

162

End page:

175

Detailed Resource Type:

Article

Format:

application/pdf

Resource Identifier:

0860-7796 ; oai:rcin.org.pl:147322 ; IChB B-28

Source:

Library of Institute of Bioorganic Chemistry PAS

Language:

pol

Language of abstract:

eng

Temporal coverage:

1988-2010

Rights:

Creative Commons Attribution BY-SA 4.0 license

Terms of use:

Copyright-protected material. [CC BY-SA 4.0] May be used within the scope specified in Creative Commons Attribution BY-SA 4.0 license, full text available at:

Digitizing institution:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Original in:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open