Subtitle:

Strategy of directed RNA degradation and selected examples of its usein antiviral therapy

Publisher:

Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS

Abstract:

Over the last decade, antisense oligodeoxynucleotides and ribozymes haveemerged as valuable biochemical tools and promising therapeutic reagents inmedicine. This review describes the basic principles of their use in the strategyof directed RNA degradation. The rules for the rational choice of targeted RNAsequences, the properties of available RNA cleaving tools, as well as the majorproblems that limit the effectiveness of this new technology, are discussed. Selected examples of the successful use of antisense oligonucleotides and ribozymesas antiviral agents are presented.

Relation:

Biotechnologia, vol.56, 1 (2002)-.

Volume:

56

Issue:

1

Start page:

57

End page:

70

Detailed Resource Type:

Article

Format:

application/pdf

Resource Identifier:

0860-7796 ; oai:rcin.org.pl:138381 ; IChB B-52

Source:

Library of Institute of Bioorganic Chemistry PAS

Language:

pol

Language of abstract:

eng

Temporal coverage:

1988-2010

Rights:

Creative Commons Attribution BY-SA 4.0 license

Terms of use:

Copyright-protected material. [CC BY-SA 4.0] May be used within the scope specified in Creative Commons Attribution BY-SA 4.0 license, full text available at:

Digitizing institution:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Original in:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open