Mossakowski Medical Research Center Polish Academy of Sciences. Department of Neuromuscular
Muscle segment examination in electron microscopy
Po A 4-year-old patient was examined. A biopsy of quadriceps sinister was performed. Electronmicroscopy analysis revealed ultrastructurally changed myofibres. The vast majority of muscle fibers were characterized by centrally located nuclei, usually single or in number of two (Fig. 1,2,3,4,5,6.) In some fibers in the longitudinal section we observed a centrally arranged row of many nuclei and the evident loss of myofibril was seen (Fig. 7). The disruption of the contractile apparatus was observed, especially near the cell nuclei (Fig. 8,9,10). Abundant connective tissue was visible (Fig. 11). Ultrastructural and clinical picture suggests centronuclear myopathy associated with inappropriate BIN1 gene activity.
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Mossakowski Medical Research Institute PAS
Library of the Mossakowski Medical Research Institute PAS
1 lut 2022
21 kwi 2020
25
https://rcin.org.pl./publication/151012
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opis 70/12 | 1 lut 2022 |
Fidziańska-Dolot, Anna (1930–2015)
Fidziańska-Dolot, Anna (1930–2015)
Fidziańska-Dolot, Anna (1930–2015)
Fidziańska-Dolot, Anna (1930–2015)