Subtitle:

Preliminary study on alginate scaffold application for chondrocytes transplantation into the rat bladder wall

Publisher:

Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS

Abstract:

Cultured chondrocytes seeded on appropriate scaffold can be used in treatment of vesico-uretheral-reflux. Aims; influence of alginate scaffold on extracellular matrix production by rats chondrocytes. Observation of alginate degradation in rat bladder. Dedifferentiated chondrocytes were seeded onto alginate fibers and alginate gel beads and stained with alcian blue. Alginate was injected in bladder wall of 10 rats with following histological examination (H-f E and alcian blue). Chondrocytes became round on alginate fibers and glycosaminoglicane positive in alginate beads. Volume of the implanted alginate decreased after 8'*’ week. Alginate gel allows chondrocytes to reexpress phenotype.

Relation:

Biotechnologia, vol.66, 3 (2004)-.

Volume:

66

Issue:

3

Start page:

213

End page:

224

Detailed Resource Type:

Article

Format:

application/pdf ; application/pdf

Resource Identifier:

0860-7796 ; oai:rcin.org.pl:119342

Source:

Library of Institute of Bioorganic Chemistry PAS

Language:

pol

Language of abstract:

eng

Temporal coverage:

1988-2010

Rights:

Creative Commons Attribution BY-SA 4.0 license

Terms of use:

Copyright-protected material. [CC BY-SA 4.0] May be used within the scope specified in Creative Commons Attribution BY-SA 4.0 license, full text available at:

Digitizing institution:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Original in:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open