Godawska, Anna ; Pękala, Elżbieta ; Kieć-Kononowicz, Katarzyna
The comparison of praziquantel biotransformation in silico and in vitro
Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS
Praziquantel (PZQ) is a drug which is used by choice to schistosomiasis treatment. Currently, it is used in malaria treatment. PZQ undergoes extensive metabolism in human body, mainly in liver, by two cytochrome P-450 isoenzymes 2B1 and 3A. As a result of these biotransformations, numerous mono- and dihydroxylated derivates in B, C and D rings are formed. Only one metabolite has been identified and described, it is 4-hydroxypraziquantel (4-OH-PZQ). So far, the metabolites out of PZQ biotransformation were obtained under the influence of Ciinnighamelle echinulata and Beauveria bassiana. There were the derivatives in position C7 and in D-ring (position is unknown).
Biotechnologia, vol.68, 1 (2005)-.
0860-7796 ; oai:rcin.org.pl:112068 ; IChB B-64
Library of Institute of Bioorganic Chemistry PAS
Creative Commons Attribution BY-SA 4.0 license
Institute of Bioorganic Chemistry of the Polish Academy of Science
Institute of Bioorganic Chemistry of the Polish Academy of Science
Oct 2, 2020
Feb 4, 2020
112
https://rcin.org.pl./publication/140338
Edition name | Date |
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Porównanie metabolizmu prazikwantelu in silico i in vitro | Oct 2, 2020 |
Godawska, Anna Kieć-Kononowicz, Katarzyna
Latacz, Gniewomir Pękala, Elżbieta Kieć-Kononowicz, Katarzyna
Borkowska, Bożenna
Ziółkowski, Piotr Babula- Skowrońska, Danuta Kaczmarek, Małgorzata Cieśla, Agata Sadowski, Jan