Tytuł:

The comparison of praziquantel biotransformation in silico and in vitro

Inny tytuł:

The comparison of praziquantel biotransformation in silico and in vitro

Twórca:

Godawska, Anna ; Pękala, Elżbieta ; Kieć-Kononowicz, Katarzyna

Wydawca:

Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS

Data wydania/powstania:

2005

Temat i słowa kluczowe:

biotechnology

Abstrakt:

Praziquantel (PZQ) is a drug which is used by choice to schistosomiasis treatment. Currently, it is used in malaria treatment. PZQ undergoes extensive metabolism in human body, mainly in liver, by two cytochrome P-450 isoenzymes 2B1 and 3A. As a result of these biotransformations, numerous mono- and dihydroxylated derivates in B, C and D rings are formed. Only one metabolite has been identified and described, it is 4-hydroxypraziquantel (4-OH-PZQ). So far, the metabolites out of PZQ biotransformation were obtained under the influence of Ciinnighamelle echinulata and Beauveria bassiana. There were the derivatives in position C7 and in D-ring (position is unknown).

Czasopismo/Seria/cykl:

Biotechnologia, vol.68, 1 (2005)-.

Tom:

68

Zeszyt:

1

Strona pocz.:

215

Strona końc.:

222

Typ zasobu:

Text

Szczegółowy typ zasobu:

Article

Format:

application/pdf

Identyfikator zasobu:

0860-7796 ; IChB B-64

Źródło:

Library of Institute of Bioorganic Chemistry PAS

Język:

pol

Język streszczenia:

eng

Zakres czasowy:

1988-2010

Prawa:

Creative Commons Attribution BY-SA 4.0 license

Zasady wykorzystania:

Copyright-protected material. [CC BY-SA 4.0] May be used within the scope specified in Creative Commons Attribution BY-SA 4.0 license, full text available at:

Digitalizacja:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Lokalizacja oryginału:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Dofinansowane ze środków:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Dostęp:

Open