Enantioselective bioreduction of propentofylline using yeast in water and organic solvents
Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS
Propentofylline (PPT) is a drug used in the treatment of both vascular dementia and Alzheimer type dementia. Hydroxy-metabolites of propentofylline (OHPPT) also demonstrate the same biological activity as the parent compound. As steroisomers of HOPPT are not commercially available, we had to produce them for pharmacological and pharmacokinetic studies. The aim of this study was to find the strains of Saccharomyces cerevisiae yielding enantiomerically pure (R)- or (S)-l-(5-hydroxyhexyl)-3-methyl-7-propylxanthin (OHPPT) from PPT. In this paper, we present the results of stereoselective reduction of PPT into OHPPT when catalysed by whole cells of baker’s and a few strains of wine yeast in water and organic solvents.
Biotechnologia, vol.77, 2 (2007)-.
0860-7796 ; oai:rcin.org.pl:87126
Library of Institute of Bioorganic Chemistry PAS
Creative Commons Attribution BY-SA 4.0 license
Institute of Bioorganic Chemistry of the Polish Academy of Science
Institute of Bioorganic Chemistry of the Polish Academy of Science
Oct 2, 2020
Dec 6, 2019
82
https://rcin.org.pl./publication/113511
Edition name | Date |
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Enantioselective bioreduction of propentofylline using yeast in water and organic solvents | Oct 2, 2020 |
Latacz, Gniewomir Pękala, Elżbieta Kieć-Kononowicz, Katarzyna
Borkowska, Bożenna
Ziółkowski, Piotr Babula- Skowrońska, Danuta Kaczmarek, Małgorzata Cieśla, Agata Sadowski, Jan
Godawska, Anna Pękala, Elżbieta Kieć-Kononowicz, Katarzyna