Enantioselective bioreduction of propentofylline using yeast in water and organic solvents
Komitet Biotechnologii PAN ; Instytut Chemii Bioorganicznej PAN
Propentofylline (PPT) is a drug used in the treatment of both vascular dementia and Alzheimer type dementia. Hydroxy-metabolites of propentofylline (OHPPT) also demonstrate the same biological activity as the parent compound. As steroisomers of HOPPT are not commercially available, we had to produce them for pharmacological and pharmacokinetic studies. The aim of this study was to find the strains of Saccharomyces cerevisiae yielding enantiomerically pure (R)- or (S)-l-(5-hydroxyhexyl)-3-methyl-7-propylxanthin (OHPPT) from PPT. In this paper, we present the results of stereoselective reduction of PPT into OHPPT when catalysed by whole cells of baker’s and a few strains of wine yeast in water and organic solvents.
Biotechnologia, vol.77, 2 (2007)-.
0860-7796 ; oai:rcin.org.pl:87126
Biblioteka Instytutu Chemii Bioorganicznej PAN
Licencja Creative Commons Uznanie autorstwa-Na tych samych warunkach 4.0
Instytut Chemii Bioorganiczneji Polskiej Akademii Nauk
Instytut Chemii Bioorganiczneji Polskiej Akademii Nauk
2 paź 2020
6 gru 2019
82
https://rcin.org.pl./publication/113511
Nazwa wydania | Data |
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Enantioselective bioreduction of propentofylline using yeast in water and organic solvents | 2 paź 2020 |
Latacz, Gniewomir Pękala, Elżbieta Kieć-Kononowicz, Katarzyna
Borkowska, Bożenna
Ziółkowski, Piotr Babula- Skowrońska, Danuta Kaczmarek, Małgorzata Cieśla, Agata Sadowski, Jan
Nowak, Jacek K.
Godawska, Anna Pękala, Elżbieta Kieć-Kononowicz, Katarzyna