Contributor:

Mossakowski Medical Research Center Polish Academy of Sciences. Department of Neuromuscular

Place of publishing:

Warsaw

Description:

Muscle segment examination in light & electron microscopy

Abstract:

A biopsy of quadriceps of a newborn baby was performed.Electronmicroscopy analysis revealed fibers characterized by disrupted structure of the contractileapparatus or even disintegration of myofibrils. Some of myofibers weretotally devoid of contractile apparatus and apoptotic nuclei, some of which were characterized by“ruffle-like” nuclear membraine were observed. Altered mitochondria were also seen.Ultrastructural image may suggest defects LMNA gene and deficiency in laminine A/C, what isassociated with a wide spectrum of diseases. Molecular analysis is recommended.

Detailed Resource Type:

Photography ; Files

Format:

pdf

Resource Identifier:

oai:rcin.org.pl:126507

Language:

pol

Language of abstract:

eng

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open