Subtitle:

Attempt at a pharmacological prevention of the development of ischemic changes in the brain of rabbits after total ischemia

Publisher:

Zakład im. Ossolińskich - Wydawnictwo Polskiej Akademii Nauk

Place of publishing:

Wrocław ; Warszawa ; Kraków

Type of object:

Journal/Article

Abstract:

Systemic hemodynamic abnormalities, functional heart disturbances and itsstructural lesions, alteration in acid-base equilibrium and early development ofbrain edema, accompanying prolonged global cerebral ischemia are considered tobe important factors limiting restoration of brain function during recirculationperiod. It was decided to counteract these factors pharmacologically, by applyingthe following drugs: 1. Afronad (Roche) — to prevent hypertonic reaction in theearly period of ischemia, 2. Levonar (Polfa) — to keep arterial pressure during therecirculation period on the level close to control, 3. Tris (Fresenuis, A.G) — to counteractdisturbances of acid-base equilibrium, and 4. Mannitol (Polfa) — to protectagainst development of early brain edema. Experiments were carried out on 9adult rabbits, in which, under pentobarbital anesthesia (35 mg/kg b.w.), totalcerebral ischemia was produced by ligation of brain supplying arteries at their outcomepoint from the aortal arch. In all animals the pharmacological treatmentprevented successfully systemic hemodynamic disturbances, functional heart abnormalitiesand alterations of acid-base equilibrium. It extended the survival timeof 6 out of 9 examined animals to 24 h. The restoration time of the bioelectricactivity of the brain in all animals did not differ essentially from that in untreatedones. Normalization of ECoG pattern with respect to both its frequency and amplitudewas higher than in untreated animals. In all the animals secondary deteriorationof the cerebral bioelectric activity appeared arround 8th h of the recoveryperiod, worsening further during the later period of survival. Brain pathomorphologyrevealed cellular ischemic changes spread over all cerebral structures,being most intensive in the brain stem and cerebellum. In only one animal, featuresof brain edema were found. However, hemorrhagie foci, resulting from pharmacologicaltreatment were a common finding.

Relation:

Neuropatologia Polska

Volume:

23

Issue:

1

Start page:

97

End page:

118

Detailed Resource Type:

Article

Format:

pdf

Resource Identifier:

oai:rcin.org.pl:68832

Language:

pol

Language of abstract:

eng ; rus

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open