Subtitle:

Gene Expression in Neuronal Apoptosis— Looking for a Therapeutic Window

Publisher:

Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS

Description:

Polish - Japan Issue

Abstract:

Excitotoxicity — cell loss occurring after an excessive neuronal stimulation with excitatoryamino acids — has been suggested to underlie major neurodegenerative disorders. Recentstudies imply that this phenomenon may have an apoptotic character, i.e., it may be an activeprocess. In our studies, reviewed herein, we confirmed and extended this view by demonstratinga gene expression component in the processes of neuronal cell loss in three different experimentalmodels: i. kainate administration, resulting in severe damage of the limbic system; ii. high-doseMK-801 treatment, evoking selective neuroned loss in the retrosplenial cortex: iii. glutamatestimulation of dentate g3Tais neurons cultured in vitro. In conclusion, we suggest that thesedata, as well as the results of a number of other studies offer a hope that there is a therapeuticwindow for the treatment of neurodegenerative diseases, both in respect to time between theinsult and cell death, and through possible common mechanisms to be targeted by futuretherapies. One can even speculate that such therapies might aim at transcription factors, e.g.,AP-1 of a specific composition and/or executor hydrolytic enzymes, e.g., cathepsin D.

Relation:

Biotechnologia, vol.35, 4 (1996)-.

Volume:

35

Issue:

4

Start page:

132

End page:

140

Detailed Resource Type:

Article

Format:

application/pdf

Resource Identifier:

0860-7796 ; oai:rcin.org.pl:146561 ; IChB B-31

Source:

Library of Institute of Bioorganic Chemistry PAS

Language:

pol

Language of abstract:

eng

Temporal coverage:

1988-2010

Rights:

Creative Commons Attribution BY-SA 4.0 license

Terms of use:

Copyright-protected material. [CC BY-SA 4.0] May be used within the scope specified in Creative Commons Attribution BY-SA 4.0 license, full text available at:

Digitizing institution:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Original in:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open