Inny tytuł:

Perspectives for Medicinal Applications of Synthetic Oligonucleotides: Antisense Technology

Wydawca:

Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS

Opis:

Polish - Japan Issue

Abstrakt:

Pharmaceutical industry is entering the era of “chirotechnology revolution”: in many countriesjany potential drug containing asymmetry centres has to be tested in its stereochemically pureforms. In the authors’ laboratory many efforts have been made, with a certain extent of success,to stereocontrolled chemical synthesis of oligonucleoside phosphorothioates and methanephosphonates. Stability of stereoregular oligonucleotides towards selected nucleases, as well as thethermal stability of duplexes formed with DNA and RNA were investigated. Other strategiesleading to antisense oligonucleotides try to avoid P-chirality by replacement of phosphates withachiral phosphorodithioates or moieties like formacetal, sulphones, diethylsilo.xanes etc.

Czasopismo/Seria/cykl:

Biotechnologia, vol.35, 4 (1996)-.

Tom:

35

Zeszyt:

4

Strona pocz.:

91

Strona końc.:

107

Szczegółowy typ zasobu:

Article

Format:

application/pdf

Identyfikator zasobu:

0860-7796 ; oai:rcin.org.pl:146558 ; IChB B-31

Źródło:

Library of Institute of Bioorganic Chemistry PAS

Język:

eng

Język streszczenia:

eng

Zakres czasowy:

1988-2010

Prawa:

Creative Commons Attribution BY-SA 4.0 license

Zasady wykorzystania:

Copyright-protected material. [CC BY-SA 4.0] May be used within the scope specified in Creative Commons Attribution BY-SA 4.0 license, full text available at:

Digitalizacja:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Lokalizacja oryginału:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Dofinansowane ze środków:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Dostęp:

Open