Inny tytuł:

Badania ultrastrukturalne ekspresji PECAM-1/CD31 rozwijającej się bariery krew-mózg u myszy, z zastosowaniem techniki przedzatopieniowej

Wydawca:

Severus Publishing House

Miejsce wydania:

Warsaw

Typ obiektu:

Journal/Article

Abstrakt:

The aim of this study was to investigate the time of expression of the adhesion molecule platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) in the developing mouse blood-brain barrier (BBB). Ultrastructural studies employing a preembedding technique described here in demonstrate that PECAM-1 is initially expressed on the luminal and abluminal endothelial cell surfaces in the newborn animals. This adhesion molecule expression appears to increase in intensity at 7-10 days post partum and then decreases to a weak labelling of the luminal endothelial cell surfaces at two weeks after birth. Our results present immunocytochemical detection of active angiogenesis during early brain development in the mouse. Moreover, because of the important role that adhesion molecules play in immune responses in the central nervous system, upregulation of PECAM-1 prior to structural maturity of the BBB may suggest that the development of an ’’immune BBB” manifests prior to anatomical closure of the BBB in the mouse.

Czasopismo/Seria/cykl:

Folia Neuropathologica

Tom:

35

Zeszyt:

3

Strona pocz.:

163

Strona końc.:

170

Szczegółowy typ zasobu:

Article

Format:

pdf

Identyfikator zasobu:

oai:rcin.org.pl:71902

Język:

eng

Język streszczenia:

eng ; pol

Prawa:

Creative Commons Attribution BY 4.0 license

Zasady wykorzystania:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitalizacja:

Mossakowski Medical Research Institute PAS

Lokalizacja oryginału:

Library of the Mossakowski Medical Research Institute PAS

Dofinansowane ze środków:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Dostęp:

Open