Subtitle:

Zmiany w mitochondriach po ekspozycji organotypowych hodowli ludzkich złośliwych guzów glejopochodnych na 2-chloro i 2-bromo-2’-dezoksyadenozynę

Publisher:

Medical Publishing House

Place of publishing:

Warsaw

Abstract:

The effects of 2-chloro-2’-deoxyadenosine (cladribine, 2-CdA) and a closely related compound 2-bromo-2’-deoxyadenosi- ne (2-BdA) on organotypic cultures of human malignant gliomas were studied with the use of electron microscopy. The cultures grown from surgical biopsies included six glioblastomas, three anaplastic astrocytomas and low-grade fibrillary astrocytoma. After 6 to 10 days of the in vitro growth the cultures were exposed to 0.3-10 /iM 2-CdA or 2-BdA for 1 to 10 days. Mitochondrial swelling and disappearance of cristae following exposure to the tested substances were observed, but only in highly anaplastic (low-differentiated) tumor cells. The mitochondrial toxicity was dose- and time-dependent, and no difference was found between the effect of 2-CdA and 2-BdA.

Relation:

Folia Neuropathologica

Volume:

34

Issue:

1

Start page:

31

End page:

39

Detailed Resource Type:

Article

Format:

pdf

Resource Identifier:

oai:rcin.org.pl:71872

Language:

eng

Language of abstract:

eng ; pol

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open