Inny tytuł:

Chemically modified siRNA duplexes

Wydawca:

Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS

Opis:

prace przeglądowe

Abstrakt:

RNA interference (RNAi) is a powerful biological process for a sequence-specific silencing of a gene expression in diverse eukaryotic cells. Discovery of this phenomena had tremendous significance for functional genomics and development of novel gene-specific therapies. The future success of RNAi technology relies on identifying appropriate chemical modifications to improve stability, potency and in vivo cellular delivery of the effector moieties, siRNAs. The presented review attempts to describe some of the biological challenges associated with using synthetic siRNAs to effect RNAi and summarizes the role of the chemical tools in the application of RNAi technology.

Czasopismo/Seria/cykl:

Biotechnologia, vol.90, 3 (2010)-.

Tom:

90

Zeszyt:

3

Strona pocz.:

146

Strona końc.:

172

Szczegółowy typ zasobu:

Artykuł

Format:

application/pdf

Identyfikator zasobu:

oai:rcin.org.pl:71502 ; IChB B-85

Źródło:

Biblioteka Instytutu Chemii Bioorganicznej PAN

Język:

pol

Język streszczenia:

eng

Zakres czasowy:

2010

Prawa:

Creative Commons Attribution BY-SA 4.0 license

Zasady wykorzystania:

Copyright-protected material. [CC BY-SA 4.0] May be used within the scope specified in Creative Commons Attribution BY-SA 4.0 license, full text available at:

Digitalizacja:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Lokalizacja oryginału:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Dofinansowane ze środków:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Dostęp:

Open