Institutional creator:

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Contributor:

Filipkowski, Robert (Promotor) ; Magalska, Adriana (Promotor pomocniczy)

Place of publishing:

Warszawa

Degree name:

doktor

Level of degree:

2

Degree discipline :

nauki medyczne

Degree grantor:

Instytut Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego PAN

Abstract:

Obtained results provide a structural framework for elucidating molecular mechanisms that govern the altered shape and can be used for further research on the factors determining neurogenesis, which depend on the shape of the nucleus, such as the composition of nuclear lamina, chromatin organization or epigenetic mechanisms. The developed method allowed to perform a detailed three-dimensional analysis of the nuclear shape. Until now the altered nuclear shape of NSC has not been described, it has been observed in progenitor cells (type-2 cells) of adult hippocampal neurogenesis (Kempermann et al. 2004), and the presence of ELCS in three NSC has been demonstrated (Cebrian-Silla et al. 2017). Furthermore, the developed method can be used to analyze the nuclear shape of other eukaryotic cells, which can be a valuable diagnostic tool in cancer or other diseases related to nuclear shape changes.

Detailed Resource Type:

PhD Dissertations

Resource Identifier:

oai:rcin.org.pl:242417

Source:

IMDiK PAN, sygn. ZS 433 ; click here to follow the link

Language:

pol

Language of abstract:

eng

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open