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Assesment of nucler-shape alterations in neural stem cells of adult hippocampal neurogenesis
Creator: Institutional creator:Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN
Contributor:Filipkowski, Robert (Promotor) ; Magalska, Adriana (Promotor pomocniczy)
Place of publishing: Date issued/created: Degree name: Level of degree: Degree discipline : Degree grantor:Instytut Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego PAN
Abstract:
Obtained results provide a structural framework for elucidating molecular mechanisms that govern the altered shape and can be used for further research on the factors determining neurogenesis, which depend on the shape of the nucleus, such as the composition of nuclear lamina, chromatin organization or epigenetic mechanisms. The developed method allowed to perform a detailed three-dimensional analysis of the nuclear shape. Until now the altered nuclear shape of NSC has not been described, it has been observed in progenitor cells (type-2 cells) of adult hippocampal neurogenesis (Kempermann et al. 2004), and the presence of ELCS in three NSC has been demonstrated (Cebrian-Silla et al. 2017). Furthermore, the developed method can be used to analyze the nuclear shape of other eukaryotic cells, which can be a valuable diagnostic tool in cancer or other diseases related to nuclear shape changes.
IMDiK PAN, sygn. ZS 433 ; click here to follow the link
Language: Language of abstract: Rights:Creative Commons Attribution BY 4.0 license
Terms of use:Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -
Digitizing institution:Mossakowski Medical Research Institute PAS
Original in:Library of the Mossakowski Medical Research Institute PAS
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