Dicer ribonucleases play an important role in the biogenesis of small regulatory RNAs by cleaving singlestranded precursors adopting stem-loop structures (pre-miRNAs) as well as double-stranded RNAs (dsRNAs)into short RNA duplexes containing functional microRNAs (miRNAs) or small interfering RNAs (siRNAs),respectively. miRNA or siRNA together with Argonaute (Ago) proteins form RNA-induced silencing complexwhich mediates post-transcriptional gene silencing. However, there is a growing number of reports describingDicer’s functions that are not related to its ribonuclease activity, and the biogenesis of small regulatory RNAs.
Licencja Creative Commons Uznanie autorstwa-Na tych samych warunkach 4.0
Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
12 sie 2021
12 sie 2021
58
https://rcin.org.pl./publication/241591
Utyro, Olga
Matkowska, Aleksandra
Czapik, Tomasz
Gudanis, Dorota