Pokornowska, Maria

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Aktywność ludzkiej rybonukleazy Dicer wspierająca parowanie cząsteczek kwasów nukleinowych: odkrycie, charakterystyka biochemiczna i potencjalne znaczenie biologiczne

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Title: Aktywność ludzkiej rybonukleazy Dicer wspierająca parowanie cząsteczek kwasów nukleinowych: odkrycie, charakterystyka biochemiczna i potencjalne znaczenie biologiczne

Abstract:

Dicer ribonucleases play an important role in the biogenesis of small regulatory RNAs by cleaving singlestranded precursors adopting stem-loop structures (pre-miRNAs) as well as double-stranded RNAs (dsRNAs)into short RNA duplexes containing functional microRNAs (miRNAs) or small interfering RNAs (siRNAs),respectively. miRNA or siRNA together with Argonaute (Ago) proteins form RNA-induced silencing complexwhich mediates post-transcriptional gene silencing. However, there is a growing number of reports describingDicer’s functions that are not related to its ribonuclease activity, and the biogenesis of small regulatory RNAs.

Start page:

End page:

162

Detailed Resource Type:

PhD Dissertations

Format:

application/pdf

Resource Identifier:

oai:rcin.org.pl:204900

Language:

pol

Language of abstract:

eng

Rights:

Creative Commons Attribution BY-SA 4.0 license

Terms of use:

Digitizing institution:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Original in:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open

Subject and keywords:

nauki chemiczne

Object collections:

Last modified:

Aug 12, 2021

In our library since:

Aug 12, 2021

Number of object content downloads / hits:

All available object's versions:

https://rcin.org.pl./publication/241591

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Edition name	Date
Aktywność ludzkiej rybonukleazy Dicer wspierająca parowanie cząsteczek kwasów nukleinowych: odkrycie, charakterystyka biochemiczna i potencjalne znaczenie biologiczne	Aug 12, 2021