Subtitle:

The application of monoclonal antibodies to medical treatment

Publisher:

Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS

Abstract:

In this review contemporary trends in the application of monoclonal antibodies are presented.There is discussed antibody reengineering for humanization of mouse monoclonal antibodies toavoid anti-globulin reaction of patient. Recent modifications of antibody fragments are also outlined. The most common antigenic structures exposed to antibody attack are characterized. Someaspects of human monoclonal antibody production are briefly described. Three most promisingtherapeutic antibodies — bispecific antibodies, immunotoxins, and radiolabeled immunoconjugates — are presented.

Relation:

Biotechnologia, vol.21, 2 (1993)-.

Volume:

21

Issue:

2

Start page:

105

End page:

120

Detailed Resource Type:

Article

Format:

application/pdf

Resource Identifier:

0860-7796 ; oai:rcin.org.pl:155731 ; IChB B-17

Source:

Library of Institute of Bioorganic Chemistry PAS

Language:

pol

Language of abstract:

eng

Temporal coverage:

1988-2010

Rights:

Creative Commons Attribution BY-SA 4.0 license

Terms of use:

Copyright-protected material. [CC BY-SA 4.0] May be used within the scope specified in Creative Commons Attribution BY-SA 4.0 license, full text available at:

Digitizing institution:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Original in:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open