Subtitle:

Gene Expression in Neuronal Apoptosis— Looking for a Therapeutic Window

Publisher:

Komitet Biotechnologii PAN ; Instytut Chemii Bioorganicznej PAN

Description:

Zeszyt specjalny. Polish - Japan Issue

Abstract:

Excitotoxicity — cell loss occurring after an excessive neuronal stimulation with excitatoryamino acids — has been suggested to underlie major neurodegenerative disorders. Recentstudies imply that this phenomenon may have an apoptotic character, i.e., it may be an activeprocess. In our studies, reviewed herein, we confirmed and extended this view by demonstratinga gene expression component in the processes of neuronal cell loss in three different experimentalmodels: i. kainate administration, resulting in severe damage of the limbic system; ii. high-doseMK-801 treatment, evoking selective neuroned loss in the retrosplenial cortex: iii. glutamatestimulation of dentate g3Tais neurons cultured in vitro. In conclusion, we suggest that thesedata, as well as the results of a number of other studies offer a hope that there is a therapeuticwindow for the treatment of neurodegenerative diseases, both in respect to time between theinsult and cell death, and through possible common mechanisms to be targeted by futuretherapies. One can even speculate that such therapies might aim at transcription factors, e.g.,AP-1 of a specific composition and/or executor hydrolytic enzymes, e.g., cathepsin D.

Relation:

Biotechnologia, vol.35, 4 (1996)-.

Volume:

35

Issue:

4

Start page:

132

End page:

140

Detailed Resource Type:

Artykuł

Format:

application/pdf

Resource Identifier:

0860-7796 ; oai:rcin.org.pl:146561 ; IChB B-31

Source:

Biblioteka Instytutu Chemii Bioorganicznej PAN

Language:

pol

Language of abstract:

eng

Temporal coverage:

1988-2010

Rights:

Licencja Creative Commons Uznanie autorstwa-Na tych samych warunkach 4.0

Terms of use:

-

Digitizing institution:

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Original in:

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Projects co-financed by:

Program Operacyjny Polska Cyfrowa, lata 2014-2020, Działanie 2.3 : Cyfrowa dostępność i użyteczność sektora publicznego; środki z Europejskiego Funduszu Rozwoju Regionalnego oraz współfinansowania krajowego z budżetu państwa

Access:

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