Subtitle:

Biotechnology of drugs on the verge of 21st century

Publisher:

Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS

Abstract:

At present the most classical pharmaceutical technologies have reached ahigh level of industrial perfection. The best example of those achievements isthe biotechnology of penicillins. Biosynthetic penicillin production using highlyproductive strains ofPenicillium chrysogeniim is followed by enzymatic hydrolysisof the product using microbial penicillin acylase, the best sources of which arerecombinant strains of Escherichia coli. The resulting 6-aminopenicillanic acid isthe starting material for chemical synthesis of a large number of semisyntheticpenicillins. Research and development of the biotechnology of antibiotics gavesolid foundations to other biotechnological processes in the pharmaceutical industry, i.e. production of amino acids, organic acids, enzymes and enzyme inhibitors, vitamins, alkaloids, dextran, steroid drugs and others.

Relation:

Biotechnologia, vol.50, 3 (2000)-.

Volume:

50

Issue:

3

Start page:

118

End page:

140

Detailed Resource Type:

Article

Format:

application/pdf

Resource Identifier:

0860-7796 ; oai:rcin.org.pl:140403 ; IChB B-46

Source:

Library of Institute of Bioorganic Chemistry PAS

Language:

pol

Language of abstract:

eng

Temporal coverage:

1988-2010

Rights:

Creative Commons Attribution BY-SA 4.0 license

Terms of use:

Copyright-protected material. [CC BY-SA 4.0] May be used within the scope specified in Creative Commons Attribution BY-SA 4.0 license, full text available at:

Digitizing institution:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Original in:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open