Mackiewicz, Paweł ; Bączkowski, Krystian ; Sobczyński, Maciej ; Cebrat, Stanisław
Mystery of orphan Open Reading Frames (ORFans) ; Journal of Biotechnology, Computational Biology and Bionanotechnology
Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS
In spite of an increase of a number of sequenced genomes, 20-30% of Open Reading Frames (ORFs) do not show detectable sequence similarity to other sequences in databases and functions of their products have not been recognized. These ORFs are called ORFans and their abundance has been referred to as a “mystery”. A large fraction of ORFans are probably spurious non-coding ORFs generated by protein coding sequences or repeat sequences. Some ORFans are probably quickly evolving genes specific to narrow phylogenetic lineages. The most interesting group of ORFans are de novo generated genes with new functions and structures which may find some applications in biotechnology and medicine. It is also possible that some ORFans code for RNA regulatory molecules.
Biotechnologia, vol.70, 3 (2005)-.
0860-7796 ; oai:rcin.org.pl:91825 ; IChB B-66
Library of Institute of Bioorganic Chemistry PAS
Creative Commons Attribution BY-SA 4.0 license
Institute of Bioorganic Chemistry of the Polish Academy of Science
Institute of Bioorganic Chemistry of the Polish Academy of Science
Oct 2, 2020
Dec 19, 2019
230
https://rcin.org.pl./publication/118310
Edition name | Date |
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Zagadka sierocych otwartych ramek odczytu (ORF-anów) | Oct 2, 2020 |
Bączkowski, Krystian Mackiewicz, Paweł Kowalczuk, Maria Banaszak, Joanna Cebrat, Stanisław
Sobczyński, Maciej Mackiewicz, Paweł Mackiewicz, Dorota Smolarczyk, Kamila Cebrat, Stanisław
Mackiewicz, Dorota Waga, Wojciech Cebrat, Stanisław