An attempt was made to prolong rabbit-to-dog liver graft survival by pretreatment of recipients with donor species blood elements. Recipients were given intraarterially whole blood, washed erythrocytes, erythrocyte stroma, leukocytes, and rabbit plasma 1 hr befor transplantation of rabbit liver. Pretreatment with whole blood or red cells was followed by acute depletion of hemagglutinins, hemolysins, complement, and decrease in platelet and leukocyte counts. Rabbit livers transplanted at that time had a 10—20-fold longer survival time. Pretreatment with donor leukocytes only slightly prolonged graft survival, whereas rabbit plasma had no effect at all. It may be concluded that recipient circulating antibodies agglutinating donor erythrocytes are responsible for triggering the process of hyperacute rejection.
Licencja Creative Commons Uznanie autorstwa 4.0
- ; Zasób chroniony prawem autorskim. [CC BY 4.0 Międzynarodowe] Korzystanie dozwolone zgodnie z licencją Creative Commons Uznanie autorstwa 4.0, której pełne postanowienia dostępne są pod adresem:
Instytut Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego Polskiej Akademii Nauk
Biblioteka Instytutu Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego PAN
Feb 1, 2022
Sep 27, 2019
67
https://rcin.org.pl./publication/106366
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