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RCIN and OZwRCIN projects

Object

Title: ZMIANY AKTYWNOŚCI FOSFATAZY ZASADOWEJ I CYKLAZY ADENYLOWEJ W SIECI NACZYNIOWEJ MÓZGU W DOŚWIADCZALNYM ZESPOLE POREANIMACYJNYM

Publisher:

Zakład im. Ossolińskich - Wydawnictwo Polskiej Akademii Nauk

Place of publishing:

Wrocław ; Warszawa ; Kraków

Type of object:

Czasopismo/Artykuł

Abstract:

Activity of alkaline phosphatase and adenylate cyclase was evaluated in the brain vascularnetwork of rats subjected to 10 min clinical death due to cardiac arrest.Progressive decrease of both enzymes activities was noted in the early survival stages, reachingthe lowest intensity in 24th h after ischemic incident. Restitution of enzymatic activity was observed2 days later, although even then it did not reach intensity typical for normal controls. Electronmicroscopic study revealed disturbances of normal polarity of enzyme distribution in thecytoplasmic membranes of vascular endothelia. Activity of enzymes disappeared from luminalendothelial surfaces, appearing on abluminal ones and in the capillary basal membranes.Ultrastructural picture of the cerebral capillaris was additionally characterized by remarkableincrease of micropinocytic vesicles, and appearance of coated vesicles as well as canalicularstructures. Swelling of endothelial cytoplasm and widening of interendothelial clefts were alsopresent.The results obtained indicate that deep 10 min ischemia in experimentally induced clinicaldeath is leading to the impairment of transport functions in damaged cerebral capillaryvessels.

Relation:

Neuropatologia Polska

Volume:

26

Issue:

3

Start page:

335

End page:

357

Detailed Resource Type:

Artykuł

Format:

pdf

Resource Identifier:

oai:rcin.org.pl:68710

Language:

pol

Language of abstract:

eng ; rus

Rights:

Licencja Creative Commons Uznanie autorstwa 4.0

Terms of use:

Zasób chroniony prawem autorskim. [CC BY 4.0 Międzynarodowe] Korzystanie dozwolone zgodnie z licencją Creative Commons Uznanie autorstwa 4.0, której pełne postanowienia dostępne są pod adresem: ; -

Digitizing institution:

Instytut Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego Polskiej Akademii Nauk

Original in:

Biblioteka Instytutu Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego PAN

Projects co-financed by:

Program Operacyjny Polska Cyfrowa, lata 2014-2020, Działanie 2.3 : Cyfrowa dostępność i użyteczność sektora publicznego; środki z Europejskiego Funduszu Rozwoju Regionalnego oraz współfinansowania krajowego z budżetu państwa

Access:

Otwarty

Object collections:

Last modified:

Feb 1, 2022

In our library since:

Feb 22, 2019

Number of object content downloads / hits:

115

All available object's versions:

https://rcin.org.pl./publication/89883

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