Publisher:

Zakład im. Ossolińskich - Wydawnictwo Polskiej Akademii Nauk

Place of publishing:

Wrocław ; Warszawa ; Kraków

Type of object:

Journal/Article

Abstract:

The studies were carried out on 98 three-month-old Mongolian gerbils, submitted to short-term (5 or 7.5min) forebrain ischemia induced by bilateral ligation of common carotid artery. After 5-day survival animals were sacrificed by transcardiac perfusion with 10% formaldehyde. Paraffin brain sections were stained with cresyl violet and according to Kliiver-Barrera method. Pickworth benzidine method was also applied to evaluate hippocampal vascular network. Varying susceptibility of individual animals to the ischemic incydent was found. This was expressed by differences in the intensity and extent of structural lesions of CA1 pyramidal neurons. No abnormalities were found in 41.7% of animals, total neuronal loss in the CA1 sector was observed in 33.3% of cases, while the partial neuronal loss appeared in the remaining 25% of animals. Asymmetric distribution of the neuronal changes observed in 18.4% of cases was a very striking feature. Differences of the angioarchitectonics of CA1 sector as compared with neighbouring parts of Ammon’s horn were found. In the pyramidal cel layer very scarce fragments of the blood vessels were present. In adjacent cortical layers (stratum oriens and stratum radiatum) relatively dense capillary network was characterized by appearance of specific vascular loops and tangles localized on the border of stratum pyramidale. It is supposed that particular spatial arrangement of the vascular network in pyramidal layer of CA1 sector, favouring appearance of local hemodynamic and rheologic abnoramalities after temporary brain ischemia, may play an essential pathogenic role in both, selective vulnerability of this neuronal population and individual variations in the intensity and distribution of the neuronal changes.

Relation:

Neuropatologia Polska

Volume:

30

Issue:

3-4

Start page:

209

End page:

219

Detailed Resource Type:

Article ; Artykuł

Format:

application/pdf

Resource Identifier:

oai:rcin.org.pl:68547

Language:

eng

Language of abstract:

eng ; pol

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open