Contributor:

Lipkowski, Andrzej W. (Promotor)

Publisher:

Instytut Medycyny Doswiadczalnej i Klinicznej im. Miroslawa Mossakowskiego PAN

Place of publishing:

Warszwa

Description:

Bibliogr. zawiera 214 pozycji ; 140 s. : il., wykr.; 30 cm

Degree name:

doctor

Level of degree:

2

Degree discipline :

medical biology

Degree grantor:

Instytut Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego PAN

Abstract:

Multiple sclerosis (MS) is an autoimmune disease , which leads to neurodegeneration , affecting increasing number of people in the developed countries of the temperate climate.As the etiology of the disease remains still unkown, the available MS therapies are mainly symptomatic. Therapies the target specific processes involved in the pathomechanism of MS often does not show the desired effect, or carry the risk of serious side effects. It is therefore a continuous search for new treatments for multiple sclerosis. Experiments described in this paper make use of the naturally occurring phenomenon of oral tolerance , where the reduction of the immune response to previously orally administered antigen is observed. As a source of myelin antigenes we used the pig spinal cord hydrolyzate, as well as recombinant lactic acid bacteria Lactococcus lactis producing theree selectd immunogenic fragments of myelin proteins. The results indicate that the use of such preparations , administered orally to rats with induced experimental allergic encephalomyelitis (animal model of MS) attenuated the clinical signs observed in animals , and also reduced the analyzed neuroimmunological symptoms.

Detailed Resource Type:

PhD Dissertations

Format:

application/pdf

Resource Identifier:

oai:rcin.org.pl:50526

Source:

IMDiK PAN, call no. ZS 346 ; click here to follow the link

Language:

pol

Rights:

Rights Reserved - Restricted Access

Terms of use:

Copyright-protected material. Access only on terminals at the Mossakowski Medical Research Center of the Polish Academy of Sciences, may be used within the limits of statutory user freedoms.

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Programme Innovative Economy, 2010-2014, Priority Axis 2. R&D infrastructure

Access:

Closed